Industrial enterprises are under pressure to innovate faster, reduce costs, and improve safety. Simulation platforms like NVIDIA Omniverse, Unity, and Unreal Engine have emerged as critical tools in this transformation. In the era of Industry 4.0, organizations can no longer rely on siloed tools or traditional design methods; instead, they must leverage cutting-edge platforms to reduce physical trial-and-error, enhance workforce training, and optimize production through digital twins, AR/VR, and real-time rendering. This white paper provides a comparative study of these leading platforms to help decision-makers evaluate the best fit for their needs. The future of industrial simulation will undoubtedly be shaped by OpenUSD standardization for interoperability, the fusion of AI with simulation for predictive design, and XR-enabled workforce training that merges digital and physical realities.